Enhanced susceptibility to stress and seizures in GAD65 deficient mice.
Reduced gamma-aminobutyric loreal tahiti acid (GABA) inhibition has been implicated in both anxiety and epilepsy.GAD65-/- (NOD/LtJ) mice have significantly decreased basal GABA levels in the brain and a lowered threshold for seizure generation.One fifth of GAD65 -/- mice experienced stress-induced seizures upon exposure to an open field at 4 weeks